---
title: "Profhilo"
description: "Profhilo — a bio-remodelling treatment with 64 mg of pure high- and low-molecular-weight hyaluronic acid, injected at just 10 points, to firm, hydrate and improve laxity on the face and neck."
url: https://uniqskin.gr/en/profhilo
language: en
author: "Maria Paraskevopoulou, MD — Dermatologist - Venereologist"
published: 2026-10-20
last_reviewed: 2026-10-20
---

[Maria Paraskevopoulou](https://uniqskin.gr/en/maria-paraskevopoulou), Dermatologist - Venereologist  
Last updated: 20 October 2026

# Profhilo

> Profhilo is an injectable **bio-remodelling** treatment with **64 mg of pure high- and low-molecular-weight hyaluronic acid** and no chemical stabilisers. It is injected at just **10 strategic points** on the face, “spreads” beneath the skin and stimulates collagen and elastin production, improving laxity, hydration and radiance — with a natural result and no downtime.

With age, the skin doesn’t only lose hydration; it also loses “support”. Collagen and elastin decrease, the skin thins and starts to sag, especially in the lower face and neck. **Profhilo** was designed precisely for this problem: it does not fill wrinkles or change your features, but improves the quality and firmness of the whole skin. At UniqSkin we choose it when laxity and loss of elasticity are the main concern.

## What is Profhilo?

Profhilo is a medical device made by the Swiss company **IBSA**. Each 2ml pre-filled syringe contains **64 mg of hyaluronic acid** — one of the highest concentrations on the market — combining high and low molecular weights.

What makes it unique is the patented **NAHYCO®** technology: instead of chemical cross-linking agents (like those used in fillers), the hyaluronic acid is stabilised by **thermal processing**. This creates “hybrid cooperative complexes” that are:

-   **100% free of chemical stabilisers**, so very well tolerated by the body;
-   **very fluid**, so they spread evenly beneath the skin instead of staying in one spot;
-   **slow-releasing**, extending the action of the hyaluronic acid.

Profhilo’s hyaluronic acid is produced by bio-fermentation, at exceptionally high purity.

## How it works

Profhilo combines two actions:

-   **Hydration**: hyaluronic acid holds water and deeply hydrates the tissues, with a visible improvement in radiance and texture.
-   **Bio-remodelling**: the gradual release of hyaluronic acid stimulates fibroblasts to produce new collagen and elastin, while also supporting the fat cells of the subcutaneous tissue. The result is denser, more elastic, firmer skin.

Because it spreads, a small number of injections is enough to rejuvenate a whole area.

## The BAP technique: 10 injection points

Profhilo is applied with the **BAP (Bio Aesthetic Points)** technique: **5 points on each side of the face**, chosen in anatomically “safe” areas, away from large vessels and nerves, where the product spreads ideally:

-   on the cheekbone,
-   beside the nose,
-   in front of the ear,
-   on the chin,
-   at the angle of the jaw.

A small amount is injected at each point and then spreads naturally into the surrounding area. A similar protocol is used for the neck.

## Who it is for

Profhilo is suitable for men and women, usually from age 30 onwards, with:

-   **Skin laxity** on the face, especially the lower third and the jawline.
-   **Loss of elasticity** and firmness.
-   **Fine lines** and a tired, dull look.
-   **Dehydration** that doesn’t improve with skincare.
-   **Laxity on the neck**, an area that is hard to treat with other injectables.

It is also ideal for anyone who wants a **natural result**, without added volume.

## Treatment areas

-   **Face**
-   **Neck**
-   **Décolletage**
-   **Back of the hands**

The Profhilo family also includes **Profhilo Structura**, for volume loss in the midface, and **Profhilo Body**, for body areas such as the arms, knees and abdomen.

## The benefits

-   **Firmness** and a better-defined facial contour.
-   **Deep hydration** and radiance.
-   **Smoothing** of fine lines and improved texture.
-   **A natural result**, without changing your features.
-   **Only 10 injections**, in a short session.
-   **No downtime**.

## Profhilo or filler?

Both are based on hyaluronic acid, but they play completely different roles:

-   **[Fillers](https://uniqskin.gr/en/fillers)** are dense, cross-linked gels that stay where they are placed, to **add volume** or correct a specific wrinkle or area (e.g. lips, cheekbones, nasolabial folds).
-   **Profhilo** is fluid and **spreads**, improving the **quality** of the whole skin — firmness, elasticity, hydration — without adding volume.

That is why the two treatments are often combined.

## Profhilo or Jalupro Super Hydro?

Both belong to the wider category of [skin boosters](https://uniqskin.gr/en/skin-boosters):

-   **Profhilo** contains only pure hyaluronic acid (64 mg), is applied at 10 points and mainly targets **laxity** and skin remodelling.
-   **[Jalupro Super Hydro](https://uniqskin.gr/en/jalupro-super-hydro)** combines hyaluronic acid (80 mg) with amino acids and peptides, and mainly targets **hydration** and **rebuilding** the skin with the building blocks of collagen.

The choice depends on what your skin needs; we will discuss it together during your medical assessment.

## The procedure

-   **Assessment**: We assess the degree of laxity and the quality of your skin and plan the protocol.
-   **Preparation**: The skin is cleansed and, if you wish, an anaesthetic cream is applied. The injection points are marked with a pencil.
-   **Injection**: With a very fine needle, a small amount of Profhilo is injected at each of the 10 points.
-   **Duration**: The treatment takes about 15–20 minutes.
-   **Protocol**: The initial course consists of **2 sessions one month apart**. For more pronounced laxity or the neck, a third session may be needed. Maintenance sessions follow, usually about every 6 months.
-   **Results**: Hydration and radiance show within the first few days. Firming develops gradually as new collagen is produced, peaking after the second session.

## Before and after the treatment

**Before:**

-   Avoid alcohol for 24 hours before the session.
-   If you take aspirin, anti-inflammatory or anticoagulant medication, let us know — **do not stop it without your doctor’s advice**.
-   Come without make-up.

**After:**

-   Don’t press or massage the injection points, and avoid make-up for 24 hours.
-   Avoid intense exercise for 24 hours.
-   Avoid saunas, steam rooms and intense heat or sun for a few days.
-   Don’t have another aesthetic treatment in the area for at least 2 days.
-   You can return to your daily activities straight away.

## Combining with other treatments

Profhilo combines beautifully with:

-   **[Botox](https://uniqskin.gr/en/botox)**, for expression lines in the upper face.
-   **[Fillers](https://uniqskin.gr/en/fillers)**, for targeted volume restoration.
-   **[Jalupro Young Eye](https://uniqskin.gr/en/jalupro-young-eye)**, for the area around the eyes, where Profhilo is not applied.
-   **[Microneedling with Dermapen](https://uniqskin.gr/en/dermapen)** and **[LED phototherapy (Dermalux)](https://uniqskin.gr/en/dermalux)**, to improve texture and radiance.

## Safety

Profhilo has a very good safety profile, as it consists of high-purity hyaluronic acid without chemical additives, which the body metabolises naturally. After treatment, small wheals appear at the injection points and usually settle within 24 hours; mild redness, tenderness or a small bruise may also occur. A medical assessment always comes first; the treatment is not recommended in cases of active infection or inflammation in the area, pregnancy/breastfeeding, bleeding disorders or a known allergy to hyaluronic acid.

## Frequently Asked Questions

1.  **Is it a filler?**
    
    No. Although it contains hyaluronic acid, Profhilo does not add volume or change your features. It spreads beneath the skin and improves its firmness and quality.
    
2.  **Does it hurt?**
    
    The treatment is well tolerated, as there are only 10 injections with a very fine needle. An anaesthetic cream can be applied if you wish.
    
3.  **How many sessions do I need?**
    
    Usually 2 sessions one month apart, followed by maintenance sessions. For more pronounced laxity, a third session may be suggested.
    
4.  **How long do the results last?**
    
    Duration varies from person to person, depending on age, skin quality and lifestyle. With maintenance sessions about every 6 months, the result is kept steady.
    
5.  **Can it be used on the neck?**
    
    Yes. The neck is one of the areas where Profhilo gives particularly good results, improving laxity and texture without adding volume.
    
6.  **What is the ideal age?**
    
    Usually from 30 onwards, when collagen production starts to decline. It also gives very good results in more mature skin with laxity.
    
7.  **Profhilo or Karisma?**
    
    Both improve skin quality without adding volume. Profhilo relies on hyaluronic acid alone, while [Karisma](https://uniqskin.gr/en/karisma) also contains recombinant human collagen, with an emphasis on rebuilding the dermis. A medical assessment will show which suits you.
    

Not sure whether Profhilo, a skin booster or mesotherapy suits you best? See our [comparison guide](https://uniqskin.gr/en/blog/profhilo-vs-skin-boosters-vs-mesotherapy).

## Conclusion

Profhilo is one of the most innovative treatments for skin laxity and skin quality. With just 10 injections of pure hyaluronic acid and no chemical additives, it gives firmer, more hydrated and more radiant skin, with a completely natural result. At UniqSkin we design a personalised protocol, on its own or combined with other treatments, for the best possible results.

---

## Contact & appointments
- **UniqSkin Dermatology** — Maria Paraskevopoulou, MD — Dermatologist - Venereologist
- Address: Leof. Marathonos 80, Anixi 145 69
- Phone: +30 210 8004544, +30 6943009046 · info@uniqskin.gr
- Book an appointment: https://uniqskin.gr/en/book-appointment
- Last updated: 2026-10-20