NCTF 135 HA

NCTF (New Cellular Treatment Factor) is an injectable poly-revitalising solution by Fillmed that combines free hyaluronic acid with around 60 active ingredients — vitamins, amino acids, minerals, coenzymes, nucleic acids and antioxidants. Delivered by mesotherapy, it nourishes the skin at a cellular level, stimulates collagen and restores hydration, radiance and firmness. It is a minimally invasive treatment with minimal downtime.

Over the years, the skin gradually loses hyaluronic acid, collagen and the nutrients that keep it hydrated and bright. NCTF 135 HA is one of the most recognised mesotherapy solutions in the world: rather than “filling” an area like a filler, it supplies the skin with a complete “cocktail” of nutrients that creates the ideal environment for it to regenerate on its own. At UniqSkin we use it as a top choice for overall rejuvenation of the face, neck, décolleté and the area around the eyes.

What is NCTF?

NCTF (New Cellular Treatment Factor) was developed in 1978 by Dr. Michel Tordjman and is today produced by the French company Fillmed (formerly Filorga). It is a certified medical device injected into the skin using a mesotherapy technique.

The name “135 HA” refers to the version of the product enriched with free (non-cross-linked) hyaluronic acid at a concentration of 5 mg/ml. Unlike the plain NCTF 135 version, the 135 HA version adds this hyaluronic acid, offering immediate and more intense hydration — which is why it is the most widely used choice for anti-aging.

How it works

Unlike a classic filler, NCTF does not add volume. It works as a bio-revitaliser: it delivers directly into the mesoderm all the “building blocks” and nutrients the skin needs to function properly. In doing so, it:

• Hydrates deeply thanks to free hyaluronic acid, which can hold up to 1,000 times its weight in water.
• Stimulates fibroblasts to produce new collagen and elastin.
• Protects cells from oxidative stress thanks to its antioxidants (glutathione, vitamins C & E).
• Improves overall skin quality: texture, density, tone and radiance.

The composition

The strength of NCTF 135 HA lies in its rich “cocktail” of around 60 active ingredients:

• Free hyaluronic acid (5 mg/ml): for immediate and deep hydration.
• 12 vitamins: support cellular metabolism and fibroblast function.
• 24 amino acids: the building blocks for collagen and elastin synthesis.
• 6 minerals: essential cofactors for metabolism and collagen production.
• 6 coenzymes: regulate and activate metabolic reactions.
• 5 nucleic acids / nucleosides: support cellular DNA/RNA synthesis.
• Antioxidants (glutathione, vitamins C & E): neutralise free radicals.

What it treats

NCTF is ideal for overall rejuvenation and is suited to:

• Dull & tired skin that has lost its radiance.
• Dehydration and loss of freshness.
• Fine lines & superficial wrinkles on the face, neck and décolleté.
• Laxity & loss of density in mature skin.
• Uneven skin tone and signs of photoaging.
• Dark circles & thin skin in the eye area.
• Prevention, for younger ages wishing to maintain their skin quality.

The benefits

• Deep hydration that is restored within the very first week.
• Visible radiance and a more rested, fresh look.
• Firmness & elasticity thanks to collagen stimulation.
• Smoothing of fine lines and improved texture.
• A more even skin tone and antioxidant protection.

According to the manufacturer’s data, a full NCTF 135 HA protocol is associated with a noticeable increase in skin tonicity and density, significant collagen stimulation and an immediate improvement in radiance.

The procedure

• Consultation: Every treatment begins with an assessment of your skin and your goals.
• Preparation: We thoroughly cleanse the skin and, if needed, apply a topical anaesthetic for added comfort.
• Application: The solution is injected with very fine needles (30G/32G) as superficial microblebs, or with dedicated mesotherapy devices. For the delicate eye area, Nanosoft technology is often used — a three-microneedle system that ensures a virtually painless, precise and even application.
• Protocol: An initial course of 3 sessions, spaced roughly 2–3 weeks apart, is usually recommended. Maintenance sessions follow, typically twice a year.
• Results: Radiance and hydration are visible from the first sessions, with fuller results developing gradually over the following weeks.
• Downtime: Minimal. Mild, transient redness or small bumps may appear at the injection sites and resolve quickly. Avoiding intense sun exposure for 48 hours and strenuous exercise for 24 hours is recommended.

Clinical evidence

The efficacy of NCTF 135 HA has been evaluated in a clinical study. In a randomised, multicenter trial of 146 participants, NCTF 135 HA was compared with an anti-aging cream. The group that received NCTF showed a statistically significant reduction in superficial wrinkles on the face, neck and décolleté, as well as increased hydration as early as the first week. The treatment was found to be effective and well tolerated, with most adverse events being mild and resolving within 48 hours.

Combining with other treatments

NCTF combines beautifully with other treatments for a complete result:

• Microneedling with Dermapen, to enhance absorption and collagen production.
• LED phototherapy (Dermalux), for extra soothing and radiance.
• Jalupro Young Eye, for targeted nourishment and rejuvenation in the eye area.

Safety

NCTF 135 HA is a biocompatible, minimally invasive product with a very good safety profile. As with any injectable treatment, transient redness, slight swelling or tenderness may appear at the injection sites. A medical assessment always comes first; the treatment is not recommended in cases of active infection or inflammation in the area, pregnancy/breastfeeding or a known allergy to any of the ingredients.

Frequently Asked Questions

1. How is it different from a filler?

   NCTF is not a filler and does not add volume. It is a bio-revitalising solution that nourishes the skin at a cellular level and stimulates collagen production, improving its quality and radiance.

2. What is the difference between NCTF 135 and NCTF 135 HA?

   Both contain the same rich cocktail of nutrients. The 135 HA version additionally contains free hyaluronic acid (5 mg/ml), offering more intense and immediate hydration.

3. Does it hurt?

   The treatment is well tolerated. Very fine needles are used and, if needed, a topical anaesthetic. With Nanosoft technology the experience is virtually painless.

4. When will I see results?

   Hydration and radiance are often visible within the first few days. Fuller results develop gradually as the course of sessions is completed.

5. Which areas can it be applied to?

   It is applied to the face, neck, décolleté, the area around the eyes, as well as the back of the hands.

Conclusion

NCTF 135 HA is one of the most complete mesotherapy solutions for overall skin rejuvenation. By supplying the skin with a full cocktail of nutrients, it restores hydration, radiance and firmness from the inside out. At UniqSkin we design a personalised protocol, on its own or combined with other treatments, for the best possible results.